I really am enjoying this game, but as a long time player of Roguelike games, I would love to be to use that type of control scheme in this game, I know the point and click interface made it more accessable to new players, but I find the keyboard only control system more precise.
You can use the keyboard controls WASD or arrow keys to move around. Due to the nature of the game involving an inventory,items,active skills and so on,i don't think its feasible to play without the mouse.