I'm very new to DoD, and as a hopeless Nethack addict, I was very excited to get into the game. I'm sort of frustrated, though, because my first 'real' game (i.e. excluding exploration deaths, learning what the skill trees look like, etc) ended in a crash that also ate my saves. I'm not sure exactly what caused it, but I had swords maxed out (so I'm Not Left Handed, Counters, etc. could have been in effect) and had just struck - possibly killed - a wight who was floating over a stairwell leading down. I've really enjoyed the game, but losing four hours of very solid progress on my first major run has definitely curbed my initial enthusiasm... Here's hoping this is not a regular problem.
Sorry to hear that. Can you look inside your game folder for any .dmp files? It might help us figure out what happened.
Ah, that sucks. Well, all I can suggest is that you give the latest beta patch a try here: http://community.gaslampgames.com/threads/dredmor-1-1-3-beta-feedback-thread.5193/ as it fixes a few crashes.