A month ago my brothers and I got together on Skype with a friend to turn Dungeons of Dredmor into a drinking game, hilarity ensues. The rules we were using at the time were pretty hardcore, but they were as follows: Everyone must play Going Rogue w/ Permadeath. You must random your character sheet and play with your first roll each time you die. Each time you die you must finish your beer (we were each using 12oz cans at the time). Each time you level up everyone else must take a drink. Each time you beat a floor you get to make up a rule. (i.e. each time told to drink more booze for mana you must drink etc.) It was pretty fun, two of us died like 7 times in a row, you wind up sitting a bit catching up on your beers, but lemme tell you how hard that first level of XP is after you're nice and plastered with a terrible build. It was a lot of fun! It should be noted that the denizens of Dredmor become stronger when said user is in an intoxicated state, proceed with caution.
Good, hope you guys have fun! It's a great way to hang out with a pal that's too far away to go have some beers with too.