First off, I want to say that this is a fantastic game! I am a long time rogue-like player and I am enjoying playing. I am running the latest version of Dredmor (downloaded from Steam on 1/29/12). Shortly after entering dungeon level two I stepped onto a "Satanic Displacement Glyph" and found myself next to a boss monster. I then chose to cast "Froda's Jump Discontinuity" at which point I was immediately presented with a Windows 7 dialog stating that Dredmor has stopped working. After confirming, I was dropped back to the desktop. The system error and system out log files did not point out any obvious error or crash output. I was running in full screen mode at 1920x1200. If there are any other details that I can provide, I will be happy to do so.
That's incredibly strange, but it doesn't seem like there's anything in particular that you did that would help pinpoint why it crashed, sadly. We'll keep an eye out.
They can't follow you through glyphs, so next time, try running in a circle and going back through the glyph. Bummer to hear about that, though!