It works! For anyone curious, this is using a Rift CV1 with Virtual Desktop. So, it's not VR as most would think of it, since you're still playing the game on a 2D screen (while floating in space), but that screen can be IMAX sized if you want. Text is surprisingly readable, although some of the tooptips were a bit of a strain. Performance was surprisingly great! Loaded up my most recent game with population 70 and had no slowdowns or hiccups.