If you ever make a Dungeons of Dredmor II I'd like to have control of a whole party of adventurers, not just one.
If they would do a sequel, I'd be more in favor of having actually multiple dungeons and an overland map. Maybe add in quests. I can already picture quests inspired by Monty Python and the Holy Grail. "Go forth and bring us a Shrubbery!" "We seek the Holy Grail!" "No thanks, we already have one!"
Which brings up another issue that maybe possible could be implemented in the current game, they should have a shrubbery as one of the possible random quest macguffins (ie. alongside with the glove, the blue lutefisk, the statue, etc.)