Got this game via the Humble Bundle, and love it so much I went back and doubled the size of my HIB donation. But to the point: I just launched up Steam, and it immediately started downloading a new version. Once the download was done (and I'd stopped running victory laps around the living room in anticipation of the awesomeness of the new update), I hit the play button. The Dredmor launcher showed up in my dock (I'm on a Mac, OS 10.6.8), but never opened the window for choosing screen size, etc. It crashed back to the Steam window with the "send a report to Apple" screen. I've tried three times now, and rebooted Steam, but it keeps crashing. Gonna reboot my computer and try again, but here's an early heads up that there may be a problem with the 1.0.8 Dredmor update, at least the Steam for Mac version. UPDATE: Rebooting my computer did nothing. 1.0.8 still won't open up on my Mac.
My crash is not as serious. Crashes for me when I click on a vending machine with a chosen burglary skill.