So, just got my first time kill on going rogue with perma death. I thought I'd sign up and share why poor Dreddie was defeated because usually I kill myself in some stupid way (last time I found Dredmor I threw a rather badly aimed holy hand grenade and blew myself to unholy bits). http://i.imgur.com/o9ItLkt.png for full size.
If you look up "poor tactical positioning" in the dictionary, you see this image. I've never seen that happen, so grats on your first kill!
Looks like one of the Lead Diggles was playing a prank on Lord Dredmor. Maybe Vlad Digula or Lord Digglebrows.