Finding tons of loot on the floor and your backpack is already full to the brim? Grab stuff on your cursor, pile it all in one spot, go sell stuff then go back and pick it all up with full auto-loot enabled. The voiceover guy will sound REALLY ANGRY. Hehe. Or maybe I'm easily amused.
Use Golemancy Level 6 on an entire dungeon floor. Summon dozens of pets. Set a macro to press the space bar 100,000 times at 1 second intervals. Take a nap.
Spamming-shift-clicking on that item that I really wanna pick up, but my backpack is full. Y-Y-Y-Y--Y-Y-Y-Y-Y-YOUR INVENORY IS F-F-F-F-UUUUUUL-UL-UL-UL-UL-UL-UL!!!!!!!! Announcer Guy certainly does get irritated Another Stupid Fun Trick: "Oh snap, it's a boss Arch Diggle!" *Ninja Vanish* *Run to Max Sight Distance* *Pull out my best single-target Crossbow Bolts* Pew pew pew! *laugh*
double click on a tile to move, the turn counter doesn't advance and enemies can't move/your buffs don't wear down.
If a monster zoo is near a shop you can use Brax as a shield. Just pick up some of his merchandise and he'll protect you.