Sometimes an icon of your skillset disapear when hovering the mouse cursor over then. It happened to me on random generation, and I didn't get what caused it (seems to be random too). The skill isn't removed from the choices, just the icon is disapearing. Maybe later i'll do more tests. Here's a screenshot of it: Thanks!
This happens if you hover your cursor over a skillicon in your skillbar while its skillicon in the big field is behind one of the other icons in your skillbar. At least that's what causes it for me.